256 



OMENTAL PLAGUE 



CHAP. 



weight of 10 cc. of the plague prophylactic caused the same decisive 

 constitutional disturbance, as manifested by a rise of body tempera- 

 ture of over 3° F., as did intravenous injection of a mass of bacilli 

 amounting to three-fourths of the growth uniformly covering the 

 slanting surface (6 centimetres by 2 centimetres) of an agar culture. 

 It is important to bear this in mind, since the fact will again be 

 referred to when comparison is made of the relative merits of 

 injection of sterilised (solid) culture and of Haffkine's (broth) 

 prophylactic. In order to show that this constitutional disturbance, 

 qua body temperature, is real, I mention here an experiment made on 

 a companion rabbit, No. 4, which animal unfortunately succumbed 

 immediately after the second injection, and on post-mortem 

 examination was found to be affected with extensive psorospermosis. 



Babbit No. 4 



First subcutaneous injection of 10 cc. plague prophylactic on 

 June 17: — 



There is here decided rise of temperature (3° F.) the day after 

 the injection, and this was maintained on the day following. Also 

 there is observed a curious initial fall of body weight, with rise 

 again as the temperature decreased after an initial rise. 



