22 QUATERCENTENARY STUDIES IN PATHOLOGY 



egg has been normally fertilised. Thus in lower animals, by artificial 

 means, such as shaking, compression, increase of temperature, altering 

 the action of gravity or changing the osmotic pressure, the early blasto- 

 meres may be separated and each give rise to an embryo. Loeb and 

 Bataillon, by changing the degree of concentration of the surrounding 

 medium, brought about separation of blastomeres and double malforma- 

 tions. Hence it has been suggested that the production of double 

 malformations is favoured by pathological changes in the mucous 

 membrane of the Fallopian tube and uterus, causing alteration in its 

 secretions. 



(196) 



