lO QUATKRCRNTENARY STUDIES IN PATHOLOGY 



evidence of karyokincsis, and the cells were evidently in a state of great 

 activity. Colloid was, comparatively speaking, scanty ; many of the 

 small alveoli indeed shewed no signs of colloid in the interior. The 

 colloid in the large alveoli had shrunk away from the epithelial lining, 

 and shewed round its margin a vacuolated appearance. It frequently 

 contained desquamated epithelial cells, and in some instances leucocytes. 

 In sections stained with eosin and haematoxylene it usually shewed a 

 somewhat patchy staining, which differed very markedly from the homo- 



Fig. 5. —Section of Thyroid Gland (Case i). 

 Shews columnar shape of the lining epithelium. Zeiss Obj. D, Oc. 4. 



geneous staining of the colloid of normal thyroid. Small deposits of 

 colloid were often seen between the alveoli, lying in what appeared to be 

 lymphatic spaces. The blood vessels, although fairly numerous, were 

 not dilated. The connective tissue between the alveoli was somewhat 

 scanty. Scattered sparsely through the specimen were small deposits of 

 lymphoid cells (Fig. 6). These deposits were of irregular shape, and 

 consisted of a small central mass closely packed with cells, which radiated 



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