12 QUATERCENTENARY STUDIES IN PATHOLOGY 



Regarding the condition of the dogs after the establishment of the 

 fisttda, I have noted undoubted nervous symptoms in two of them 

 (Nos. 2 and 4), but no definite symptoms in the other two (Nos. i and 3). 

 The following is an account of the behaviour of the dogs : — 



Dog I. — Female, weighing 25 lbs. The operation was performed on 

 January 21st, 1904. For six days after it no food was taken, there being 

 slight fever. From January 28th, to February 12th (15 days) a diet of 

 300 gr. bread and 50 gr. butter was taken, and during this period the 

 dog increased in weight from 21 to 23 lbs. On two occasions (viz., on 

 the 4th and 9th of February) meat extract was added to this diet. A 

 period of six days' fasting followed, and then a bread and butter period 

 of eight days, after which flesh was given in gradually increasing 

 amounts (see Table I.). 



At no stage were any phenomena noted like those described by 

 Pawlow and Massen, but marked nephritis with accompanying symptoms 

 set in, which at one stage looked as if they would prove fatal. On this 

 account it may be of interest to describe the history more in detail. 



From the very outset albuminuria was observed. Until the day after 

 the first administration of meat extract, however, the proteid was present 

 only in traces, but on this day it increased distinctly in amount, the 

 increase continuing daily until, after a few days, about 50% of the total 

 nitrogen excreted was present as proteid. Fatty, cellular and hyaline 

 casts were also abundantly present in the urine, which also contained 

 globular bodies soluble in ether. The high excretion of nitrogen 

 occurring even when no food was given is accounted for by the presence 

 of proteid. The animal became very much emaciated. CEdema of the 

 abdominal wall was very marked, and an interstitial keratitis developed. 

 On account of the presence of so much proteid, the quantitative estima- 

 tions of the various urinary constituents were rendered very difficult, and 

 had to be discontinued because of their inaccuracy. The dog was 

 carefully treated, being fed for some time largely on milk ; and her 

 condition gradually improved, the proteid diminishing slowly till it had 

 almost disappeared. After two months she was removed to the country 

 where she became perfectly well. After four months she was killed, and 

 a post mortem examination made. It was found that the ligature had 

 been applied above the vena pancreatico-duodenalis, and that the opening 

 between the vena cava and vena porta had closed. Nothing abnormal 



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