ON ECK'S FISTULA 1 5 



but regular and deep ; the pupils still very contracted. She now lay 

 quietly on her side and made no attempts to assume the erect posture. 



For the next 2j hours very little change was noted in her condition, 

 except that the respirations became laboured and the pulse of lower 

 tension ; the rectal temperature fell to 38*5 ° C. ; the extremities became 

 cold to the hand. At 5*48 p.m. she was wrapped in cloths to keep 

 her warm, and in moving her for this purpose, convulsions were induced, 

 in which the head and neck were thrown far back on the body and 

 the fore limbs stiffly extended. The respirations became very rapid and 

 gasping, and the pulse almost imperceptible. This convulsion lasted 

 7 minutes, and as she had then become quiet, she was left till next 

 morning, when she was found dead, lying in the same position as when 

 last seen. Autopsy revealed the existence of a perfect Eck's fistula 

 without any collateral circulation. 



It will be seen that the dogs observed by us behaved in general 

 exactly like those of the St. Petersburg workers, and that a flesh diet 

 seemed to bring on the symptoms. The marked nephritis, which was 

 noted in dog i, was no doubt due to disturbance in the kidney circulation, 

 the exciting cause perhaps having been the excess of meat extractives 

 given the animal on the day before the albuminuria became marked. 



The Chennical Examination of the Urine. 



This was carried out in the case of three of the above dogs (Nos. i, 

 3 and 4). 



Nencki and Hahn {vide page 270) have shown that in the urine of 

 Eck's fistula dogs there is a relative increase in the excretion of 

 ammonia and of uric acid, and relative decrease in that of urea. They 

 also found carbamates in the urine. In our investigation we therefore 

 examined total-nitrogen (Kjeldahl-Gunning method) ; urea-nitrogen 

 (Morner and Sjoqvist and Folin's method) ; purin-nitrogen (Camerer- 

 Arnstein method) and ammonia-nitrogen (Folin's method). We likewise 

 tested for the presence of carbamates by the Abel-Drechsel method, and 

 later, by the method elaborated by us and described elsewhere.* 



* Macleod and Haskins : The Quantitative Estimation of Carbamates. American 

 Journal of Physiol., 1905, xiii., p. 17. 



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