LEUCOCYTOSIS AND OPSONIC CONTENT OF SERUM 15 



Opsonic indices at different times during the day : 



ii-30a.m. 3-15 p.m. 6-15 p.m. 



Rabbit I. I'o -91 i-o 



10 a.m. 3 p.m. 

 Rabbit II. I'o i*o 



11 a.m. 5-20 p.m. 

 Rabbit III. ro -95 



10 a.m. 3-30 p.m. 5*30 p.m. 

 Rabbit IV. i*o I'o -94 



10-30 a.m. 3 p.m. 5*30 p.m. 



Rabbit V. ro -98 1*3 



(N.B. — This rabbit received 2 cc. of a 5 % solution of carbolic acid. Vide Exp. 17.) 



11*30 a.m. 3-15 p.m. 5*20 p.m. 



Rabbit VI. I'o I'o j-o 



11 a.m. I p.m. 

 Guinea-pig I. I'o i-o8 



ii'5oa.m. 3 p.m. 4*45 p.m. 



Guinea-pig II. I'o 1-2 1-07 



From the above results it will be gathered that during periods from 

 three to twenty-four hours the opsonic index shows very little variation. 

 In fact, the figures 12 and g may be taken as the upper and lower limits 

 of what one may either call " physiological opsonic variation " or more 

 probably " experimental error." 



IV. — Details of experimental results. 



I. — Sodium Cinnamate. 



In Charts I. to VII., are represented, graphically, the leucocytic and 

 opsonic variations obtained by the inoculation of sodium cinnamate in 

 rabbits and guinea-pigs. 



The various leucocyte types are expressed in absolute values per cub. 

 mm. The non-granular cells in which are included the small and large 

 mononuclears and transitional cells are classed together for convenience, 

 as it was invariably found that these cells reacted in the same direction 

 to the chemical agents employed for inoculation. 



(335) 



