1 8 QUATERCENTENARY STUDIES IN PATHOLOGY 



Exp. III. (Chart III.) Rabbit. Intravenous inoculation. 



Half the usual quantity of sodium cinnamate was inoculated. No 

 appreciable rise in the total count resulted, but the polynuclear percentage 

 again rose from 34 to 69, while the non-granular and mast cells fell 

 markedly. 



No change took place in the opsonic content. 



Exp. IV. (Chart IV.) Rabbit. Intraperitoneal inoculation. 



In the peripheral circulation, no hyperleucocytosis took place, as has 

 so frequently been observed after intraperitoneal inoculation, but the 

 relative neutrophilia in the circulating blood is evidence of a possibly 

 much greater quantitative leucocytic reaction in the peritoneal area. 



No change took place in the opsonic content after six hours. 



Exp. V. (Chart V.) Rabbit. Intraperitoneal inoculation. 



A very slight absolute rise in the leucocyte count was evident in the 

 peripheral circulation, but the relative neutrophilia was even more 

 pronounced than in the last experiment. The percentage rose from 44 

 to 80 in four hours, and was still high (76 %) ^^ the sixth hour. 



No appreciable variation was noted in the opsonic content during the 

 period of observation. 



Exp. VI. (Chart VI.) Guinea-pig. Intraperitoneal inoculation 



(•5 grm.). 



In spite of the fact that the inoculation was intraperitoneal, an 

 enormous rise of the total leucocytes in the peripheral circulation took 

 place four hours after injection. The period of hyperleucocytosis was, 

 however, very transitory, the count returning to its initial level at the 6th 

 hour. The rise affected solely the polynuclear series. It is notable, also, 

 that the relative neutrophilia persisted for some time after the hyper- 

 leucocytosis had disappeared. 



No variation took place in the opsonic content. 



Exp. VII. (Chart VII.) Guinea-pig. Intraperitoneal inoculation. 



The guinea-pig employed, presented a slight initial leucocytosis with, 

 however, no derangement of the differential count, so that the figures, 

 though high (19,200), must be taken as normal for that animal. 



(338) 



