LEUCOCYTOSIS AND OPSONIC CONTENT OF SERUM 



19 



The total leucocytes rose in four hours to 27,200, and this rise was 

 accompanied by a marked neutrophilia. 

 No opsonic variation was evident. 



Remarks on Sodium Cinnamate 

 — Leucocytosis. 



The intravenous inoculation of 

 sodium cinnamate in rabbits pro- 

 duced the most marked hyperleu- 

 cocytosis, while the intraperitoneal 

 inoculation produced little or no 

 rise in the total leucocytes of the 

 peripheral circulation. It must be 

 insisted, however, that the relative 

 neutrophilia, which is a constant 

 feature even in the absence of 

 hyperleucocytosis, is as much an 

 expression of leucocytic stimula- 

 tion as the latter, and differs from 

 it only in degree. 



The duration of the period of 

 hyperleucocytosis after a single 

 inoculation was always short, in 

 some cases lasting only a few 

 hours. On examination, twenty- 

 four hours after inoculation, the 

 blood picture was invariably 

 normal. 



The results obtained by us, 

 in the case of sodium cinnamate 

 leucocytosis, are in entire accord- 

 ance with those recorded by 

 Richter(39), Richter and Spiro(4o) 

 and Batty Shaw (^i), and in entire 

 disagreement with those of Char- 

 teris and Cathcart (^s), who evi- 

 dently missed the period of 

 VII. hyperleucocytosis entirely, by 



(339) ■ XI 



VI. 



