LEUCOCYTOSIS AND OPSONIC CONTENT OF SERUM 23 



Unfortunately, no count was made at the end of 48 hours, but, at the end 

 of 72 hours, there was still a very slight relative neutrophilia, although 

 the total count had returned to practically normal limits. 



Estimations of the opsonic content during the first 24 hours revealed 

 no change either towards tubercle bacilli or staphylococci. 



Exp. XL (Chart XI.) Guinea-pig. Intraperitoneal inoculation 

 (5 cc. of Tallianine). 

 In this animal a fairly well-marked hyperleucocytosis and neutro- 

 philia were again registered, but the duration was much shorter, the 

 blood-picture returning to the normal at the end of 24 hours. 



The opsonic content during the period of hyperleucocytosis was not 

 appreciably affected. 



Exp. XII. (Chart XII.) Guinea-pig. Intraperitoneal inoculation 

 (5 cc. of Tallianine). 



On this occasion, a slight leucopenia was apparent at the end of 

 the first hour, the fall affecting mostly the polynuclears. At the end 

 of the third hour, however, a very marked hyperleucocytosis and neutro- 

 philia were evident. At the fifth hour this condition was still present 

 though the neutrophilia had slightly diminished. At the end of 24 hours 

 there was still a well marked hyperleucocytosis, but the neutrophilia had 

 entirely disappeared. A late response on the part of the mononuclears 

 was now evident. The opsonic content, during the observation period, 

 presented only slight fluctuations. 



Exp. XIII. (Chart XIII.) Guinea-pig. Intraperitoneal inoculation 

 (5 cc. of Tallianine). 

 At the end of three hours, the leucocytes had mounted from 7000 to 

 19,800, and relative neutrophilia was conspicuous. The opsonic content 

 was not estimated in this experiment, advantage being taken of the 

 hyperleucocytosis, to test the phagocytic power of the newly-formed 

 polynuclears (vide infra.). 



Exp. XIV. (Chart XIV.) Guinea-pig. Intraperitoneal inoculation 



(5 cc). 

 In this experiment, the animal was kept under observation for six 

 days after inoculation, and blood examinations were made every day. 



(343) 



