LEUCOCYTOSIS AND OPSONIC CONTENT OF SERUM 35 



Exp. XXX. (Chart XXX.) Guinea-pig. Intraperitoneal inoculation 



(4 cc). 



Complete blood and opsonic estimations were made every hour after 



injection. At the end of the first hour, the total leucocytes had fallen 



slightly, but a relative neutrophilia was already conspicuous (70%). 



At the end of the second hour, the leucocytes had risen to 14,900, and 



an enormous neutrophilia was present (90 °/J. 



At the end of the third hour, the neutrophilia was still high, though the 

 total leucocytes had fallen. 



XXVII. 



XXVIII. 



XXIX. 



During the next hour a well marked hyperleucocytosis occurred 

 (26,600) which had quite gone in the course of an hour. The neutro- 

 philia was persistent. 



A very marked rise in the opsonic index, both to staphylococcus and 

 tubercle, took place between the fourth and fifth hours after inoculation. In 

 both cases the rise was very transitory. There was no apparent negative 

 phase. It is notable also that the relative neutrophilia reached its 

 maximum two hours before the period of hyperleucocytosis. 



Exp. XXXI. (Chart XXXI.) Guinea-pig. Intraperitoneal inoculation 



(3 cc). 

 At the end of the second hour, there was a marked hyperleucocytosis 

 with very slight relative neutrophilia. The opsonic index was double its 



(355) Y I 



