LEUCOCYTOSIS AND Ol'SONIC CONTENT OF SERUM 



37 



In spite of the slight absolute changes, however, the relative changes 

 in the direction of neutrophilia have been quite conspicuous, though more 

 transitory than in the case of tallianine. 



The leucocytes of the guinea-pig react much more vigorously to 

 nuclein than those of the rabbit. 



In sharp contradistinction to substances like sodium cinnamate and 

 tallianine, nuclein invariably produces a marked rise in the opsonic 

 index, probably of a non-specific nature. 



An experiment was made to determine whether the direct addition of 

 nuclein to normal serum altered the opsonic index of the latter. The 

 result was negative. 



7. — Papayotin-albumose. 



The papayotin-albumose was prepared by digesting washed fibrin 

 with papayotin at 37° C for two days, filtering and precipitating the 

 albumose of the filtrate by alcohol. The resulting precipitate was then 

 dried over H2 S04 in vacuo. Intraperitoneal injection of | gm. of this 

 substance in rabbits produced a marked relative neutrophilia, but did 

 not affect the opsonic index. 



8. — Aleurone Emulsion. 



The following experiment was made with aleuronat emulsion.* 

 A rabbit was inoculated intraperitoneally with 5 cc. of a 5 % 

 emulsion of aleuronat. At the end of 24 hours the opsonic power of the 

 serum was unchanged. At the end of 36 hours the animal was killed. 

 On opening the abdomen a yellowish cheesy mass was found, adherent 

 to the parietal pertitoneum. It weighed 1*5 gm., and was composed of 



* The aleurone used was aleuronat purissimum, prepared by R. Hundhausen. Hamm, i. W. 



(357) 



