UNION OF COMPLEMENT 31 



thus the amount of combined complement will be diminished. 

 Even if this allowance be made, there is a certain falling-off 

 in the additional amount of complement taken up for each 

 additional dose of immune-body when higher multiples 

 are used. In the case of rabbit's complement the amount 

 taken up is proportionately less than in the case of guinea- 

 pig's complement, especially with the higher multiples of 

 immune-body. 



The facts stated refer to the serum rabbit v. ox. Results 

 with othe rsera are given incidentally below (pp. 71-83). 

 The following may be quoted in illustration : 

 Experiment XLII. Immune-body, Rabbit v. Guinea-pig. 



2 D (doses) of IB took up 0-08 c.c. guinea-pig's C. 

 8 0-288 



Experiment LX. Immune-body, Eabbit v. Guinea-pig. 

 1 D of IB took up 0-2 c.c. rabbit's C. 



3 0-45 

 10 1-16 



Experiment LXII. Immune-body, Guinea-pig v. Eabbit. 



1 D of IB took up 0-04 c.c. of guinea-pig's C. 

 10 0-36 



Experiment LXIII. Immune-body, Guinea-pig v. Eabbit. 

 1 D of IB took up 0-22 c.c. of rabbit's C. 



10 M2 



Experiment LXXIII. Immune-body, Eabbit v. Ox. 

 1 D of IB took up 0-04 c.c. of ox's C. 



4 0-05 

 8 0-05 



This last combination forms an exception to the general 

 rule, as here almost the maximum amount of combined 

 complement is obtained with a little more than one dose 

 of immune-body (p. 83). 



As a rule, therefore, multiple hcemolytic doses of immune- 

 body combined with red corpuscles lead to the union of increased 

 amounts of complement, and in some instances the comple- 



