142 PROPERTIES OF ANTI-SERUM TO SERUM 



ment may be treated with an immune-body artificially 

 developed for these corpuscles, or we may depend in some 

 instances on the natural lysis which may be produced by a 

 normal serum. (In this latter case there is of course in the 

 serum a natural immune-body or Zwischenkorper which 

 acts along with the complement.) The following may be 

 cited as examples. The anti-serum rabbit v. ox (along 

 with the homologous serum) deviates (a) guinea-pig's com- 

 plement as tested either with ox's or rabbit's corpuscles 

 treated with the corresponding immune-body, and (b) 

 rabbit's complement when tested in the same way ; it also 

 deviates (c) dog's complement as tested by the natural lysis 

 of dog's serum on rabbit's corpuscles. The anti-serum 

 rabbit v. man deviates both (a) rabbit's and (b) guinea-pig's 

 complement when tested with ox's corpuscles treated with 

 immune-body, and also (c) cat's complement when tested 

 by the natural lysis of guinea-pig's corpuscles by cat's 

 serum. If we regard the specific substance in the anti- 

 serum as the homologue of an immune-body, these results 

 show that many complements are taken up through the 

 medium of the same immune-body. Analogous results are 

 obtained in the case of haemolytic immune-bodies. 



We have, however, met with the following two exceptions, 

 though we have made no very extended series of observa- 

 tions, and probably many others will be found to obtain. 

 The anti-serum rabbit v. ox (along with the homologous 

 serum) does not deviate ox's complement in the natural 

 lysis of rabbit's corpuscles by ox's serum. Again, the anti- 

 serum rabbit v. guinea-pig does not deviate rabbit's com- 

 plement when guinea-pig's corpuscles treated with immune- 

 body from the rabbit are used as the test 1 . It is thus 

 1 In this case there is a striking analogy to what has been described 

 above (p. 77) in the case of haemolytic immune-bodies, viz. that 

 increased amounts of immune-body for guinea-pig's corpuscles did not 

 take up (or deviate) increased amounts of rabbit's complement when 

 guinea-pig's corpuscles + immune-body were used as the test, whereas 



