306 



Dr. L. Eogers. On the Physiological 



[June 6, 



In the fourth experiment the onset of convulsions and the final 

 failure of the circulation, as evidenced by the sudden fall in blood 

 pressure, were both delayed by the use of artificial respiration. With 

 this exception, it will be seen from the table that both the respiration 

 and the circulation fail more and more rapidly as the dose of the 

 poison is increased, until with a dose of 4 milligrammes per kilo, 

 weight (1/250,000 of the body weight) the respiration was affected in 

 1 minute and had entirely ceased in 2J minutes, while the circulation 

 failed in 3J minutes. The exact sequence of events can be best illus- 

 trated by the data and tracings of the following two typical experiments, 

 being Nos. 3 and 5 in the above table. 



Experiment 3. 



Rabbit, weight 1J kilos., under chloroform. Cannula in the carotid 

 artery, connected with a Gad's manometer. Respirations recorded 

 with Sandstrom's instrument. 3 milligrammes (2 milligrammes per 

 kilo, weight) of dried Enhydrina poison injected into the external 

 jugular vein dissolved in 075 c.c. of 0*9 per cent. NaCl. 



