346 Drs. A. D. Waller and E. H. Aders Plimmer. [June 12, 



hat, selbst wenn es in grossen Dosen, z. B., 1 Gramm auf einmal direkt 

 ins Blut (eines Kaninchens) gebracht wird." 



The experiments to be described below are in direct contradiction of 

 this very clear and positive statement. 



In a series of experiments made with a different object in view, 

 viz., to determine the effect upon isolated nerve of different kinds of 

 sugar, it was noticed more than once that syrups made with ordinary 

 beet-sugar had a faint cadaveric odour reminiscent of the choline and 

 neurine solutions that had just been under investigation, and the 

 suspicion was naturally aroused that the taint of the samples in ques- 

 tion might be due to the presence of betaine or of allied alkaloid. I 

 attempted (and failed) to separate betaine from such a sample; Dr. 

 Plimmer has undertaken the task again with a positive result. 



Physiological Data. The action of betaine (as hydrochloride) upon 

 isolated ntrve and the isolated heart has been described in the previous 

 paper. All that remained to do in the present connection was to re-try 

 upon warm-blooded animals the effects upon respiration and upon blood 

 pressure the effects of intravenous injections of betaine. 



Experiments. 



B = Commercial betaine (Merck). 

 B' = Betaine from sugar (Plimmer). 



