1903.] On the Ceils of Malignant Growths in Man. 499 



different sub-cultures were experimented with at many different ages, 

 and that in only two cases (viz., Experiments 8 and 97) was a pure 

 Anthrax growth obtained when the infected water had been raised to 

 100 C., we conclude that any heating of Anthrax spores in water to 

 this or any higher temperature, even for the shortest practicable time, 

 is almost certain to insure their destruction. 



What is the lower limit of destructive temperature, when the heating 

 is prolonged, we have not attempted to determine, but we hope to 

 make some observations on this point both with regard to Anthrax and 

 some other spore-bearing bacilli, and to give the results in a further 

 communication. 



" On the Kesemblanees Exhibited between the Cells of Malignant 

 Growths in Man and those of Normal Keproductive Tissues."* 

 By J. BRETLAND FARMER, F.K.S., J. E. S. MOORE, F.L.S., and 

 C. E. WALKER. Keceived December 8, Bead December 10, 

 1903. 



The object of this communication is to draw attention to certain 

 important cytological transformations exhibited during the develop- 

 ment of malignant growths in man. We believe that the changes we 

 are about to describe are diagnostic of malignant as opposed to those 

 of a benign character. Furthermore, if our conclusions are well 

 founded, they may at the same time serve to throw light upon the 

 nature of the processes involved in the formation of these growths, 

 and we hope that they may also serve as a point of departure for 

 further investigations on the more remote etiology of the 



tS We wish, however, at the outset, to disclaim all intention of formu- 

 lating at the present time any theory as to the nature of these various 

 remote causes! although, as will be seen in the sequel, our observation 

 indicate certain directions along which such causes may perhaps 



once state as the results of our investigations on a 

 large number of malignant growths, including numerous 

 Cafcinor^ta and Sarcomata, that we have been * . 

 number of definite and serial changes in the ^. t 



sense a joint one. 



