262 ARCHIVES OF NEUROLOGY AXD PSYCHIATRY 



all later trials, he lifted the lid with his left hand, sometimes holding it back 

 with his left knee or with his head while reaching into the box with his left 

 hand, or with the left hand while reaching with his head. On the eighth and 

 all later trials, he pulled the plug with his left hand and used the right only as 

 a prop. 



Throughout the retention tests his activities were centered on the 

 plug, hasp, and lid. He never attempted to lift the lid until the hasp 

 was disengaged. When the lid was raised the next acts seemed defi- 

 nitely directed to holding it up, and though clumsy, the movements were 

 clearly not random. 



EFFECTS OF SUBSEQUENT DESTRUCTION OF THE CORPUS STRIATUM 



A hroad bladed cautery was next passed through the old lesion into 

 the corpus striatum and drawn back and forth through this nucleus. 

 The wound was closed, and the animal was kept under observation 

 until his death eight days later. 



On recovery from anesthesia, the animal showed marked spasticity 

 of the left side. The left arm was usually hyperextended, although in 

 walking or clinging to a perch the arm and leg assumed a normal 

 posture. The left side was very weak, and when he walked the arm 

 and leg frequently collapsed suddenly. He took food with his right 

 hand and placed it in his mouth. When I held a bit of food, he drew 

 my fingers to his mouth with the palm of his left hand, but without 

 closing the fingers, which remained hyperextended. 



On subsequent days, he used both right and left hands in walking, 

 climbing and grasping food. The left side was spastic and very weak 

 but capable of a variety of fine adaptive movements. The right side 

 -bowed a coarse tremor, and athetoid movements of the left arm 

 appeared when the right was used. There was marked paralysis of the 

 pharynx. He kept his mouth stuffed with food or shavings but was 

 unable to swallow. 



At no time was the paralysis as marked as after the destruction of 

 die cortex. Indeed the condition showed no resemblance to hemiplegia, 

 but, except for the pharyngeal paralysis, was essentially that described 

 by Wilson 4L ' for lesions of the striate nucleus without involvement of 

 the pyramidal tracts. The possibility that the recovery from the initial 

 paralysis was due to vicarious functioning of the striate nucleus seems 

 thus definitely to be ruled out. The animal did not recover sufficiently 

 for retention tests after this operation, but his behavior when released 

 in the laboratory -bowed that his general orientation was unaffected. 



42. Wilson, S. A. K. : An Experimental Research Into the Anatomy and 

 Physiology of the Corpus Striatum. Brain 36:427-492, 1913. 



