INTERRELATIONS OF SECRETIONS 51 



trated before puberty, is not exercised about his condi- 

 tion. In the former is a despondency and lack of force 

 caused by the crying need for these stimuli, while 

 eunuchs often have buoyant dispositions and are raised 

 to places of power and trust (12). The same parallel 

 is seen in most women following or during the meno- 

 pause, where nature, or the internal secretions, are 

 below par until adjustment is made between the endo- 

 crine organs without the ovarian stimulus. 



Just as it is difficult for the internist to think of a 

 pure type of infection, so it is hard for the endocrinolo- 

 gist to think of a single type of endocrine disturbance. 

 The makers of vaccines and the developers of new 

 ideas along this line take this fact into consideration, 

 while an autogenous vaccine contains a definite propor- 

 tion of various organism, according to the bacterial 

 count. It is very seldom that a single organism can be 

 blamed for all of the symptoms. Much less then can 

 the endocrinologist think of a disturbance of a single 

 gland because one is a dominant factor. 



Having established the relationship of various 

 glands, the application of this knowledge to clinical 

 cases becomes of importance. The first principle to be 

 adhered to is that of balance. To determine a balance 

 of internal secretions each case must be approached 

 according to the symptom complex, bearing in mind 

 that many organs may be involved in the process. For 

 instance, in cretinism: we have here a hypof unction 

 of certain glands and need to make up the deficiency. 

 We give them certain substances secreted by the thy- 

 roid, pituitary body and adrenals. As this is the purest 

 approach to a single endocrine disturbance and thyroid 

 function is not often present at all, thyroid substance 

 will have to be given in greater proportion than the 

 other glands. Better than the secretions themselves 

 is to give standardized macerated glands which, no 



