90 THE INTERNAL SECRETIONS 1920 



For this to be accomplished, it is necessary that a diag- 

 nosis be made as soon as possible. 



In five cases of typhoid fever, where no bacilli were 

 found in the blood and where the Widal-reaction was 

 already positive when I began with thyroid tablets, 

 I have not seen the slightest influence on the measure 

 of agglutination. In the same way I did not observe a 

 difference in agglutination after vaccination against 

 typhoid fever in persons taking or not taking thyroid 

 tablets. It is difficult, even often impossible, to diag- 

 nose typhoid in the beginning of the disease. If, how- 

 ever, the diagnosis is made early, we ought to think of 

 the possibility of increasing the resistance of the pa- 

 tient by giving him thyroid. Perhaps other endocrine 

 products may have the same or an even better effect, 

 but one thing is certain : Too often the endocrine sys- 

 tem is forgotten in the study and the treatment of acute 

 infectious diseases. 



BIBLIOGRAPHY 



1. Charrin (A.) : Les interventions chirurgicales en face 



des nouyelles donnes de la physiologic et de la 

 pathologic generale, Semaine med. (Paris), 1905, 

 xxv, 61. 



2. Sajous (C. E. de M.) : "Internal Secretions and Prin- 



ciples of Medicine," F. A. Davis Co. (Philadelphia), 

 1916, VII Ed., pp. 143, 623. 



3. Lorand (A.) : Insuffisance thyroidienne comme facteur 



etiologique dans la pathogenic de la tuberculose, 

 Congres de la Tuberculose (Paris), 1905. 



4. Muller (L.) : De Pinfluence de Popotherapie thyroid- 



ienne et du traitement iode sur le pouvoir hemo- 

 lytique du serum, Centralbl. f. Bakteriol. (Jena), 

 1909, 1, 462. 



5. Miiller (L.) : Recherches sur le lieu et le mode d'or- 



igine des cytoly sines naturelles (alexines et ambo- 

 cepteurs normaux) et les moyens d'en provoquer 

 Thyper secretion, Centralbl. f. Bakteriol. 1. Abt. 

 (Jena) , 1910-1911, Ivii, 577. 



6. Marbe (S.) : Les opsonines dans les etats thyroidiens. 

 (a) Les opsonines des animaux hyperthyroides, C. r. 



Soc. Biol. (Paris), 1908, Ixiv, 1058. (b) Les op- 

 sonines des animaux ethyroides, ibid., 1113.. (c) 

 Les opsonines et la phagocytose chex les myxoede- 

 mateux, ibid., 1908, Ixv, 612. 



7. Id.: (d) Action directe in vitro du corps thyroide, 



ibid., 1909, Ixvi, 432. (e) La phagocytose chez les 



