THE THYROID-OVARIAN SYNDROME 103 



after the menopause and is the type seen in the male. 

 With the progress of the condition, irrespective as to 

 which gland is first involved, the terminal condition 

 presents a predominance of the thyroid symptoms. As 

 illustrative of the terminal condition, two cases, one 

 male the other female, are cited. 



Case I. Female, married, age 38 years. One child 

 died of intestinal obstruction, three others are alive 

 and well. During the last pregnancy, four years 

 previous, she complained of headache, vertigo and a 

 slight and transient edema of the legs. At that time 

 her blood pressure, which one year previous had been 

 normal, was found to be 180 mm. systolic and a trace 

 of albumen and casts were found in the urine. The 

 diagnosis of impending eclampsia was made and she 

 was placed in the hospital under close observation. The 

 complaint of headache became so intense at the mid- 

 dle of the eighth month that a premature labor was 

 induced. After delivery the headaches became less 

 severe, the vertigo intermittent and more severe, pe- 

 riods of double vision occurred, and the blood pressure 

 and urinary findings remained as before delivery. A 

 diagnosis of chronic nephritis was made. 



The conditions remained as just described for a pe- 

 riod of two years when an intolerable itching developed 

 which kept the patient awake at night. The skin be- 

 came boggy to such a degree that larger shoes had to 

 be worn, and rings had to be removed from the fingers. 

 There was an increase of 49 Ibs. in weight. Attacks 

 of double vision became increasingly more frequent and 

 lasted longer. A backache developed about six months 

 ago. 



After the birth of the last child there was a period 

 of six months during which menstruation, while regu- 

 lar, was very profuse, but latterly it had become irreg- 

 ular being sometimes four to six weeks overdue and 

 when on time, it was scanty, being approximately one- 



