THE THYROID-OVARIAN SYNDROME 105 



lost an additional ten pounds. It might be noted that 

 while she had been on a restricted diet for several 

 years, during organotherapy she was placed on a full 

 diet. Thyroid alone in one-half-grain doses was given 

 for the next two months, with the result that she did 

 not menstruate the second month and again ten days 

 before her period had double vision for five days. The 

 medication was reinstated as before, for one month, 

 the double vision cleared up and did not return at the 

 next menstrual epoch. Between two menstrual epochs 

 she was given pituitary gland substance, and after four 

 days of medication, double vision recurred worse than 

 ever before. It subsided promptly when pituitary sub- 

 stance was discontinued. At the present time her 

 status is that of a well woman blood pressure 125 sys- 

 tolic, symptom-free, urine normal, menses normal, total 

 loss of weight 55 Ibs. 



Case II. Male, age 56 years, married, four children, 

 all alive and well ; negative family history except that 

 he is the brother of Case IV, thyroid group. About 

 seven years ago the patient noted a gradual increase in 

 weight and the onset of attacks of vertigo and short- 

 ness of breath, this last being attributed to his gain in 

 weight. Five years ago, though previously free from 

 headaches, he commenced to have violent morning 

 headaches, which aroused him from sleep at about 5 

 A. M. These headaches were frontal and temporal, 

 and wore off during the day. He had occasional itch- 

 ing of the skin at times violent enough to prevent him 

 from sleeping. He had a nocturnal polyuria. Latterly, 

 he had frequent periods during which he could not read 

 the paper because of double vision. Six months before 

 the present period he had been rejected for life insur- 

 ance because of high blood pressure. Within the past 

 year he noted a sudden dimunition in sexual power. 



Physical examination: Overweight, 30 Ibs.; blood 

 pressure, 250 mm. systolic ; face "puggy" and cyanosed ; 



