ORGANOTHERAPY AND THE ADRENALS 169 



there is a sympatheticotonic paroxysm. During the 

 second phase the clinical and pathogenic phenomena 

 are very like those of shock. 



Cazamin remarks that people inclined to sympatheti- 

 cotony are peculiarly predisposed to seasickness, while 

 the vagotonic escape. 



In the second phase, adrenalin, by mouth (the equiv- 

 alent of 6 mg. in three doses at half -hour intervals), 

 gives good results. 



During the stage of hyperadrenia he has obtained 

 absolutely constant, excellent results, both in preven- 

 tion and in curing the seasickness, from hypodermic 

 injections of neutral sulphate of atropin in doses vary- 

 ing from 0.001 to 0.002 gms. 



As we know of no dependable drug that will check 

 the functioning of the sympathetic nervous system, the 

 next best thing is to act on the antagonistic nervous 

 system. By influencing the vagus in this way with 

 atropin, we thus indirectly control the sympathetic. 

 The question whether adrenalin or atropin is called for 

 is easily answered by the oculocardiac reflex. His ex- 

 perience indicates that with one or the other of these 

 drugs we can ward off and cure practically every case 

 of seasickness. 



Another interesting class of cases comes to mind. 

 Many times the form of paroxysmal tachycardia, which 

 depends upon an imbalance between the thyroid and 

 adrenals, with a moderate excess of thyroid secretion, 

 may yield to a few doses of adrenalin in a very grati- 

 fying way. There are few services for which the pa- 

 tient is more grateful than to have the pounding heart 

 quieted down. The same remedy is almost a specific 

 for the insomnia associated with this form of endocrine 

 disturbance. Recognition of this factor will save hours 

 of sleep to the patient. 



The manifold uses and great therapeutic value of 

 adrenal extracts are, perhaps, more readily understood 



