172 THE INTERNAL SECRETIONS 1920 



adrenalin hyperglycemia is accompanied, as shown by 

 Achard and Desbouis, by a deficient glycolysis, that is, 

 a lessening of the capacity of the tissues to burn and 

 fix the glucose of the blood. 



With the assistance of Ch. Achard and A. Ribot, we 

 have taken up the question of the action of adrenalin 

 upon the consumption of glucose, and for that purpose 

 we have studied, in the dog, the characters of the 

 hyperglycemia provoked by an injection of glucose and, 

 these characters being known, the variations of this 

 hyperglycemia when a certain quantity of adrenalin is 

 injected with the sugar. In every experiment, glucose 

 was injected in aqueous solution (35 grams to the litre) 

 and at the beginning of the experiments was with- 

 drawn before the injection and then every ten minutes 

 following the injection. Our method has been done 

 following the procedure of A. Epstein, which allows 

 volume of blood in a great proportion and, therefore, 

 without altering the quantity of sugar in the blood. 

 The duration of the hyperglycemia, provoked by the 

 injection of glucose, seemed to us a most important 

 point, indicating the capacity of the organism to fix this 

 sugar. In a series of healthy dogs we obtained the fol- 

 lowing results : 



1. A dog, weighing 12 Kg., was injected with 12 

 grams of glucose ; after 2 minutes the quantity of sugar 

 in the blood went from 1 gm. per litre, to 3.10 gm. ; the 

 glycemia came back to the starting point after 40 min- 

 utes. 



2. A dog, weighing 19 Kg., was injected with 12 

 gm. of glucose; after 2 minutes the sugar went from 

 0.9 gm., to 2.65 gm. and came down to 0.90 gm., 30 

 minutes later. 



3. A dog, weighing 19 Kg., was injected with 10 

 gm. glucose : the quantity of sugar went from 1.05 gm., 

 to 2.85 gm., after 2 minutes and came back to the start- 

 ing point in 20 minutes. 



