BIOLOGICAL EFFECTS OF ADRENALIN 173 



4. A dog, weighing 15 Kg., was injected with 3.5 

 gm. glucose: the sugar went, after 2 minutes, from 

 0.95 gm., up to 1.40 gm., and was normal 20 minutes 

 after. 



5. A dog, weighing 33 Kg., was injected with 7 gm. 

 glucose: 2 minutes after the quantity increased from 

 1.15 gm., to 1.95 gm., and back to 1.15 gm., after 10 

 minutes. 



From those experiments, selected from several others, 

 we may conclude that the degree and duration of the 

 hyperglycemia provoked by the injection of glucose 

 evidently are in proportion to the amount of glucose 

 injected. The duration of that phenomenon gives very 

 clear indications and we can admit that with half a 

 gram of glucose per kilogram, the hyperglycemia lasts 

 about 20 minutes and with one gram per kilogram it 

 lasts about 40 minutes. We might wonder what be- 

 comes of the injected glucose: Part is eliminated 

 through the kidneys, as it is shown by a glycosuria fol- 

 lowing the hyperglycemia; the rest is either fixed or 

 burned up. In fact, the analysis of the gases in the 

 veinous blood or of those expired, shows the quick com- 

 bustion of the assimilable sugar, if everything is nor- 

 mal. 



The comparative study of the quantity of sugar after 

 the injection of assimilable glucose and, on the other 

 hand, after the injection of unassimilable lactose, clear- 

 ly proves the part of the destruction and fixation of 

 the sugar during the phenomenon. 



A dog, weighing 22 Kg., was injected with 15 gm. of 

 glucose: hyperglycemia disappeared 45 minutes after. 

 Some days later he was injected with 15 gm. of lactose ; 

 the quantity of sugar doubled 45 minutes after: 0.78 

 gm., at the beginning, and 1.95 gm., after 45 minutes. 



What becomes of a hyperglycemia when adrenalin is 

 injected with the glucose? We have studied this, con- 

 sidering, in each experiment, the effect of glucose alone, 



