174 THE INTERNAL SECRETIONS 1920 



then the effect of adrenalin, and lastly, the effect of 

 both together. 



A dog, weighing 15 Kg., was injected with 3.5 gm. of 

 glucose, 2 days after, with 1 mgm. of adrenalin, and 

 lastly, 2 days later, with 3.5 gm. of glucose, plus 1 mgm. 

 of adrenalin. 



Quantity of sugar in blood after an injection of: 



3, 5 gm. glucose 



3, 5 gm. 1 mg. + 1 mg. of 



glucose. adrenalin, adrenalin. 



Before 0,95 0,95 0,95 



2 min. after 1, 40 1, 70 



10 min. after 1, 10 1, 40 2, 10 



20 min. after 1, 1, 20 1, 70 



40 min. after 0, 92 1, 30 



1 hr. 20 min. after 1, 10 



2 hrs. after 0, 95 



This shows that the addition of adrenalin to glucose 

 brings an increase of sugar greater than the sum of 

 the increases brought by adrenalin alone and glucose 

 alone. In addition, this hyperglycemia lasts longer 

 since it lasts after an hour and twenty minutes. It is 

 as if the organism, under the influence of adrenalin, 

 could no longer fix and burn up the sugar : its power of 

 glycolysis seems absent. 



These experiments seem to us to develop some prac- 

 tical applications ; in therapeutics it seems to us that 

 there is an incompatibility between glucose and adre- 

 nalin : the serum containing both glucose and adrenalin 

 seems not to be used. 



But how are the conditions of hyperglycemia and in- 

 compentency of glycolysis produced? Numerous opin- 

 ions have been expressed about this. With Ch. Achard 

 and A. Ribot, we have tried to solve this problem by 

 studying the effect of an injection of adrenalin after the 

 extirpation of the pancreas. This is a problem so much 

 the more interesting as the relations between the adre- 

 nal glands and the pancreas have been recently sought 



