BIOLOGICAL EFFECTS OF ADRENALIN 175 



for (R. Pemberton & J. E. Sweet E. Gley Graham, 

 Lusk & Riche F. C. Mann & Delia Drips) . 



1. Dog weighing 10 Kg. Injection of 1 mg. of 



adrenalin. Sugar in blood 



after pancreas 

 Normal Dog. was out 



Before 0, 65 3, 20 



10 min. after 0, 80 3 



20 min. after 0, 60 3', 20 



2. Dog weighing 10 Kg., having its pancreas re- 

 moved 6 days previously. Injection of 2 mg. of adre- 

 nalin into the saphenous vein; the quantity of sugar, 

 within the following half hour, remains at 3 gm. per 



litre. Sugar in blood. 



Before 3 gm. 



After 2 mg. of adrenalin 3 gm. 



10 minutes after 3 gm. 



20 minutes after 3 gm. 



30 minutes after 3 gm. 



Such conditions do not exist if the extirpation of the 

 pancreas is not complete, and a dog, which had had the 

 pancreas removed 13 days before, but still had a stump 

 of pancreas left, as was shown by the autopsy, showed 

 an adrenalin hyperglycemia : 



Dog weighing 9 Kg., had its pancreas out on May 21, 

 was injected June 4, with 2 mg. of adrenalin. 



Sugar in blood. 



Before 1 



15 minutes after. 1, 30 



30 minutes after 1,50 



The animal was killed and a stump of pancreas about 

 the size of a pigeon's egg was found against the duode- 

 num. These experiments show that adrenalin hyper- 

 glycemia is not produced after the extirpation of the 

 pancreas. Finally, it is as if adrenalin injected into a 

 dog prevented the action of the glycolytic ferment from 

 the pancreas, its action on glucose seems indirect and is 

 suppressed by the previous suppression of that ferment 

 by the extirpation of the pancreas. 



