BIOLOGICAL EFFECTS OF ADRENALIN 177 



hemorrhages, especially near the left ventricle. Lungs 

 as usual. 



Fourth Experiment A dog, weighing 8 Kg., was in- 

 jected within an hour with 10 mg. of adrenalin. One 

 hour and a half after the beginning of the experiment 

 the animal was killed and a large amount of fluid in the 

 pericardium, with several hemorrhages in the myocar- 

 dium, were found. Lungs as usual. 



In these experiments the lungs remained uninflu- 

 enced, but in some others the opposite is the case ; and 

 on the other hand, the pericardium is not altered. 



Fifth Experiment A dog, weighing 7 Kg., was in- 

 jected with 5 mg. of adrenalin. The next day the ani- 

 mal died and at the autopsy edema of the lungs, with a 

 pink liquid in the pleural cavity, were found. The peri- 

 cardium was free from this fluid, but there were some 

 signs of hemorrhage in the myocardium on the right 

 (ventricle and auricula), and even one was found on 

 the valves of the pulmonary artery. The left part of 

 the heart was normal. 



From those experiments we may conclude that : 



1. There is an acute exudate into the pericardium 

 after certain injections of adrenalin. 



2. That liquid is slightly hemorrhagic, yet having a 

 composition different from that of the serum. 



3. That a pericarditis may occur, which is accom- 

 panied by injuries of the myocardium, especially in 

 connection with hemorrhages of the left part of the 

 heart. 



4. It does not happen when the animal has a marked 

 edema of the lungs, as if there were two fragile parts : 

 one in the lungs, which is shown by the swelling of the 

 capillary vessels, the other in the pericardium, which 

 is shown by the swelling of the pericardium. 



In cases of hypertension there may be injuries in the 

 pericardium of such a character that adrenalin is not to 

 be used in pericarditis and also in edema of the lungs. 



