178 THE INTERNAL SECRETIONS 1920 



III 



THE ACTION OF ADRENALIN ON SHIVER 



Adrenalin has an action on certain nervous manifes- 

 tations, particularly upon shiver. The experiments of 

 Professor Ch. Richet have shown that a chlorilized dog, 

 having a temperature of 34 C., was taken at first with 

 a shiver on inspiration, then when both inspiring and 

 expiring a violent shivering occurred so as to increase 

 inspiration and expiration evidently in order to raise 

 the temperature. 



Our experiments have shown that if an animal in 

 such a plight was injected with 1 mg. of adrenalin, its 

 shivering was stopped instantly, as well as the respira- 

 tion. If only % mg. were injected, the respiration 

 might not be altered, but the shivering would be 

 stopped. It seems that the center, which controls shiv- 

 ering, is more sensitive to adrenalin than the center 

 which controls respiration. 



Adrenalin momentarily stops the thermic shiver; it 

 also stops the reflex shiver observed on an animal that 

 is awake. Lastly, it prevents the development of the 

 shivering caused by the injection into the veins of cer- 

 tain substances as sugars. 



If some glucose serum is injected into a non-anesthe- 

 tized dog, immediately a violent and long continued fit 

 of shivering is produced; if, on the contrary, serum 

 containing both glucose and adrenalin is injected, the 

 shiver is not produced. Thus adrenalin seems to us an 

 excellent remedy for the shivering, whatever may be its 

 cause. 



IV 

 THE ACTION OF ADRENALIN IN ANESTHESIA 



Experimentalists do not fail to be struck with the 

 dejected look of the animal which, when awake, is in- 



