BIOLOGICAL EFFECTS OF ADRENALIN 179 



jected with adrenalin. The dog which, but a moment 

 ago, was barking and lively, becomes quiet and silent. 

 That fact must be remembered, and J. Gautrelet praises 

 the use of adrenalin in anesthesia of animals by means 

 of chloralose. His experiments show that the period 

 of the excitement before anesthesia, caused by chlora- 

 lose, is suppressed if adrenalin is injected previously. 

 In man, Pierre Delbet, Herrenschmidt, Beauvy and 

 Carlo-Oliva have considered the action of chloroform 

 on the adrenal glands. 



It seemed worthy of interest to us to study the effect 

 of adrenalin upon the resistance of guinea pigs to 

 chloroform. Under a glass bell, containing about 30 

 litres, two guinea pigs were set. They weighed the 

 same; the one was a control; the other was injected 

 under the skin with 2/10 mg. of adrenalin ; chloroform 

 vapor could be blown through the receiver. Anesthesia 

 lasted from 10 to 25 minutes, then the animals were re- 

 moved. The animals were under observation imme- 

 diately after and on the following days ; but often this 

 anesthesia was enough to cause the death of one of the 

 animals. 



The results of our experiments show : 



First, in 10 controls: 



One animal recovered. 



Nine animals died, of which 8 were under the bell 

 during anesthesia, and 1 dying after the animal had 

 been removed and was no longer under chloroform. 



Second In 10 guinea pigs having been injected with 

 2/10 mg. of adrenalin: 



Two animals died (one immediately, the other some 

 days after) . 



Eight animals recovered. 



Such figures should suffice to prove the value of adre- 

 nalin as a preventive of the shock caused by chloro- 

 form. 



