196 THE INTERNAL SECRETIONS 1920 



thyroid glands also influence carbohydrate metabolism 

 through a secondary influence on the adrenals and pan- 

 creas. The pituitary, thyroid, adrenals and gonads in- 

 fluence the metabolism of fat. 



It is known that direct lesions occur in the endocrine 

 organs and frequently certain clinical syndromes are 

 connected with such lesions of one organ or another. 

 Experience has shown that the endocrine organs are 

 closely connected with each other functionally, so that 

 a disturbance in one involves, according to the circum- 

 stances, a more or less profound disturbance in the 

 function of a smaller or larger number of the others. 

 From this we can infer that pluriglandular disorders 

 are much more frequent than disorders involving a 

 single gland of internal secretion and, therefore, the 

 administration of one or more synergists or pluriglan- 

 dular therapy, may radically alter the results in a given 

 case for the better and determine the final outcome. 



I regard endocrinology and organotherapy as of the 

 utmost importance in both the diagnosis and the treat- 

 ment of many of the problems of pediatrics. 



BIBLIOGRAPHY 



Barker (L. F.) : Some of the commoner types of dis- 

 eases of the endocrine glands, /. Med. Soc. N. Jersey 

 (Orange), 1914, xi, 493. 



Bartlett (F. K.) : A case of acromegaly and poly- 

 glandular syndrome, with special reference to the 

 pineal gland, Arch. Int. Med. (Chicago), 1913, xii, 

 201. 



Bainbridge (W. S.) : The internal secretions; some 

 clinical aspects illustrated, Maine Med. J. (Port- 

 land), Aug. 1915. 



Biedl (A.) : "Innere Sekretion, Ihre physiologischen 

 grundlagen und ihre bedentung fur die pathologie, 

 Urban & Schwarzenberg (Berlin & Wien), 1910; 

 Ibid., "The Internal Secretory Organs: Their Phy- 

 siology and Pathology," transl. by Linda Forster, 

 John Bale, Sons & Danielsson (London), 1912. 



Bandler (S. W.) : Internal secretion in obstetrics and 

 gynecology, Amer. J. Surg. (New York), 1917, 

 xxxi, 156. 



