THOUGHTS ON INTERNAL SECRETION 205 



associated with enlarged follicles at base of tongue, are 

 very apt to have an insufficiency of the medullary por- 

 tion of the adrenals. The person whose pulse is difficult 

 to find, because of a small artery, or whose uterus is of 

 the infantile type, many times is deficient, in this re- 

 spect. While I never heard it said by others, I have 

 nearly always found an adrenal medullary insufficiency 

 in persons whose pupils are chronically large. Such 

 individuals have slight resistance to infection, and they 

 are bad risks for the surgeon as well as the anesthetist. 

 On the other hand, one will occasionally find an indi- 

 vidual in whom it is quite difficult to dilate the pupil, his 

 pulse is large and full, his blood pressure up to the top 

 of normal, and, perhaps, his temperature is slightly 

 above normal. Such an individual has an especially ac- 

 tive chromaffin system, and his resistance is good. He 

 will perhaps not die of an infectious disease, but rather 

 of diabetes, nephritis, pernicious anemia or liver dis- 

 ease. He takes an anesthetic splendidly, but may lose 

 his life from the cocainization of a tooth for extraction. 

 The possibilities of adrenal therapy are scarcely 

 dreamed of as yet, even by the enthusiastic organothe- 

 rapist. 



Sajous says that carcinomatous and sarcomatous 

 growths in rats and mice have been made to disappear 

 under adrenin treatment. 6 Solis-Cohen reports some 

 wonderful results in the treatment of cardiac as well 

 as true asthma; 7 while Tyson and Jump claim to have 

 cured abdominal ascites by the same medication. 8 Per- 

 sonally, I have seen marked improvement in bronchial 

 asthma under combined pituitary and adrenal treat- 

 ment; and in hay-fever I have known as much relief 

 to follow an injection of Liquor Hypophysis as results 

 from a quarter of a grain of morphia. 



As for thyroid extract, remember that it contains 

 nature's brand of iodine, as used in the metabolism of 



