THE FUNCTION OF THE OVARY 219 



istics. There evidently is some correlation between 

 the two in normal circumstances. 7 In this connection, 

 Falta and Meyer 11 state that "those adenomata of the 

 adrenal cortex that are associated with hyperfunction 

 of the cortex are of great interest in the study of the 

 internal secretions. There is a difference in the clin- 

 ical picture according to whether they develop in the 

 entirely childish or in the juvenile or the adult organ- 

 ism. In the child there is an enormously accelerated 

 development of the body, and premature development 

 of the genitalia. The condition nearly always affects 

 girls." So marked are the consequences that it seems 

 evident that the secondary sex characteristics are 

 dependent largely on the adrenal cortex. 11 



Hypo-ovarism is a far more frequent condition than 

 over activity of the ovaries. The latter may occasion- 

 ally be found in early life accompanying pituitary dis- 

 ease, abnormal thymus atrophy, or a pineal tumor. 

 Resutling from the dyscrinism, the ovaries may func- 

 tion very early or abnormally and menorrhagia or 

 metro rrhagia may develop. Consequently, the adrenal 

 glands, being excessively stimulated by this abnormal 

 activity of the ovarian hormone, may be depleted, re- 

 sulting in the long periods of adynamia and asthenia 

 so commonly seen in ovarian cases. 6 A too rapid loss 

 of ovarian secretion causes depression and melancholic 

 conditions. 3 



In menstruation, large amounts of calcium as well 

 as other salts, are lost; consequently, too frequent or 

 profuse menstruation results in too great a loss of 

 calcium and other salts and the bones, hair, teeth and 

 nails may suffer; and an aggravating nervousness, 

 loss of sleep and irritability follow. 3 



Pepe 13 reports eleven cases of scanty milk secretion 

 successfully treated by corpus luteum. He believes 

 that there exists a hypogalactia concurrent with ovari- 

 an insufficiency, in which case the homo-organotherapy 



