THE ESSENTIAL DUCTLESS GLANDS 239 



development of the thorax, pelvis, and larynx, the voice 

 remaining high-pitched, as in the child; the muscles 

 lose their tone and the prostate and vesicula seminals 

 fail to develop, the bones of the extremities, however, 

 growing abnormally long." 



Compare this symptom complex with the syndrome 

 resulting from conditions where the testicles are in a 

 stage of hyperf unction. We find here, as we found in 

 hyperadrenia, an abnormal sexual and physical devel- 

 opment; "a general growth in stature; a premature ap- 

 pearance of secondary sexual characters, such as 

 growth of hair on the face in the male and in the arm- 

 pits, and on the pubes in both sexes; development of 

 breasts and generative organs; in short, all the signs 

 of puberty." (14) 



This similarity of symptoms produced by an in- 

 creased activity of the testicles and the adrenals, led 

 Sajous (15) to deny to the testicles a separate internal 

 secretion. He believes in the existence of "adrenal 

 rests" or small areas of chromaffin tissue outside of the 

 adrenal bodies, as in the testicles, ovaries, and pitui- 

 tary, the internal secretion of which would be identical 

 with that of the adrenals. 



The endocrine action of the ovaries in females is 

 somewhat similar to that of the testicles in men, with 

 slight modifications, however. The removal of the ova- 

 ries in the young leaves the sexual organs in an unde- 

 veloped state, while their removal in adults causes 

 atrophy of those organs, the menopause and diminished 

 sexuality. 



Space and time do not permit us to analyze the inter- 

 nal secretions of any of the other organs, as the thymus, 

 pineal, pancreas, spleen, etc. Besides, our knowledge 

 of the nature of their hormones is still very scant. 

 ORGANOTHERAPY 



There is, however, another important aspect of the 

 study of the ductless glands that we may touch upon, 



