248 THE INTERNAL SECRETIONS 1920 



loss of sleep. I informed my patient that I did not think 

 it wise to treat the diabetes heroically, as we might up- 

 set his metabolic equilibrium, as is often done in elderly 

 diabetic patients when the diet is radically changed. 

 He persisted, however, in his desire for treatment, and 

 it was administered with reluctance. The injections 

 took place as follows: September 10th, September 

 25th, October 4th, October 18th, October 27th, Novem- 

 ber 7th. At this time my patient voiced the opinion 

 that he was feeling ever so much better, and that his 

 memory had greatly improved, so much so that he had 

 written an article for a Washington paper which had 

 been accepted. He then received injections on: No- 

 vember 18th, November 28th, and December 15th. The 

 patient was so much improved mentally that he was 

 busy writing every day; his mentality was that of a 

 man of forty. He was able to express himself in defi- 

 nite terms, and recall past events that had happened in 

 the political world years ago; sleep was undisturbed. 

 He informed me that he did not become fatigued on ex- 

 ertion, either physically or mentally. 



During the course of treatment his sugar output re- 

 mained unchanged, although the polyuria and weakness 

 disappeared. This is a remarkable case in that definite 

 results were produced in a man of this age, as evidenced 

 by a dismissal of all symptoms that might be referable 

 to a final waning of all endocrine functioning. 



CASE II. Young man, aged thirty-four, instrument 

 maker by trade ; venereal history negative. A history 

 of diabetes extending back three years. Complained on 

 visiting me of general weakness, loss of weight and 

 ability to concentrate. Sexual instinct at a minimum ; 

 erection impossible. Physical examination revealed a 

 prematurely old man. Skin dry with beginning wrin- 

 kles ; heart and lungs negative. 



First injection October 17, 1919, continued for a pe- 

 riod of four months at intervals of seven days. There 

 was no dietetic treatment advised, and none indulged 

 in. On discharge, the patient was sugar free, had 

 gained thirty pounds and, as he expressed it, was feel- 

 ing like a new man. He also gained back the power of 

 erection. His spermatogenic function, which had been 

 absent for two years, returned gradually. His wife be- 

 came pregnant in May, 1920, seven months after the 



