STERILITY AND THE ENDOCRINES 249 



patient received his first injection, but unfortunately 

 miscarried at the third month. He now enjoys better 

 health than at any time during the past five years, and 

 is doing hard manual work without any appreciable 

 fatigue. 



CASE III. Female, married; no children. Men- 

 struated at the age of fifteen. Periods remained regu- 

 lar until the age of twenty-seven, usually lasting four 

 or five days ; no pain. At this time the patient came 

 home one evening to find her cousin dead in bed. Fol- 

 lowing this shock she swooned, was revived and con- 

 tinued in her usual good health, but did not menstru- 

 ate. She had suffered from amenorrhea ror the past 

 two jears, previous to consulting me. Physical exam- 

 ination revealed no obstruction or malposition of the 

 uterus. There was no tenderness over the ovarian area, 

 nor was there any leucorrhea. Skin was slightly icteric, 

 and drawn in appearance. Frontal headache was com- 

 plained of. The patient presented an apathetic appear- 

 ance. 



A specimen of the husband's semen examined on a 

 warm stage microscope showed very active sperma- 

 tozoa. His Wassermann was negative, as was that of 

 his wife. I advised routine injection of my serum. The 

 patient received one injection weekly for a period of 

 four months. During the middle of the fourth month 

 she menstruated. I visited her the following day, and 

 found that she was losing a normal amount of men- 

 strual blood. The flow continued for two days and sub- 

 sided. The next period was regular, and they have 

 continued so to the present. This patient had been 

 curetted previous to the administration of the serum, 

 without result. Undoubtedly her ovarian dysfunction 

 was due to the sudden shock she received over two 

 years ago, and as a result her endocrine equilibrium 

 was disturbed and normal stimulus did not take place. 



CASE IV. Male, aged fifty-seven; hatter by trade. 

 History elicited the fact that the patient's skin was 

 becoming dry and rough. The sexual function had been 

 impaired for the past four months, with inability either 

 to ejaculate or maintain erection. The patient was un- 

 able, at times, to sleep more than two hours a night. 

 He became uninterested in his work, lost weight and 

 strength, and presented an apathetic appearance. The 



