TREATMENT OF PERNICIOUS ANEMIA 261 



It has been noted that recent cases, as compared with 

 those that have existed during a comparatively longer 

 period, often show more serious losses of hemoglobin 

 than the more chronic cases, but usually they respond 

 more readily to treatment. 



Loss of weight during the treatment is usual and 

 varies, depending upon the location of the infection. 

 All the gall bladder cases that have come to my atten- 

 tion have lost more in weight than those in whom mouth 

 and other focal infections were prominent causes. In- 

 cidentally, I have noticed that those cases that lost 

 weight under this treatment usually have responded 

 more rapidly in the improvement of the blood picture. 

 The return of the former weight is oftentimes inex- 

 plicably delayed. 



The administration of the phylacogen not merely 

 serves to stimulate the immunity and antagonize the 

 production of the poisons which are fundamentally re- 

 sponsible for the blood picture, but the peculiar lemon 

 color of the skin disappears following the hypodermic 

 injections of the phylacogen before much improvement 

 is found in the blood picture. 



I have had most uniform results from the Mixed In- 

 fection Phylacogen. Its use should be continued until 

 no reaction is obtained from the injection. Some cases 

 have had injections for twenty-five days each month 

 for four to nine months before the immunity seemed 

 to be established and the blood picture became normal. 

 An occasional large dose which may be sufficient to 

 cause a slight chill often is of great stimulating benefit 

 after the prolonged use of this remedy. The injections 

 are best made in different parts of the body, and hypo- 

 dermically. 



The prospects in the treatment of pernicious anemia 

 ordinarily are not at all good, and it is clear that per- 

 sistence is a great factor in the treatment outlined. It 

 is also necessary to supplement the removal of the foci 



