ANGIONEUROTIC EDEMA 287 



sitive to foreign proteins of any kind, either in the 

 form of food or medicines, and these patients may re- 

 quire desensitization by the Besredka (9) method or 

 modification before biological products can be used. 

 The carbohydrate intake should be carefully regulated 

 in accordance with urinary findings. Of the endocrine 

 products, parathyroid gland to control neuromuscular 

 unbalance, and pancreas substance to reestablish nor- 

 mal work of the pancreas and antagonize the adrenals 

 are directly indicated. 



Thyroidectomized horse serum, while indicated as a 

 thyroid antagonist, almost invariably serves as a direct 

 exciting cause of increased attacks of angioneurotic 

 edema by reason of the protein-bearing serum. Thy- 

 roidectin in 5-grain capsules, three times daily, is bet- 

 ter borne. The following prescriptions have been used 

 with success by the writer : 



$ : Quinine Hydrobromide gr. v 



Iron Arsenate gr. 1/10 



Atropine Sulphate gr. 1/1000 



M. et ft. tales Caps. No. 100. 



Sig: One capsule three times daily, at meals. 



$ : Parathyroid Gland, Desiccated gr. ss 



Pancreas, Desiccated gr. ij 



Bile Salts, Powdered gr. j 



Calcium Lactate gr. jss 



M. et ft. tales Caps. No. 100. 



Sig: Two capsules four times a day between meals. 



R^SUMfi 



Angioneurotic edema is a pluriglandular hypersecre- 

 tory syndrome, in which thyroid excess is a preliminary 

 feature and adrenal hyperactivity the secondary and 

 predominating characteristic. 



Local wheal formation develops because of localized 

 vasodilation of thyroid origin, with prompt subsequent 

 fatigue-paralysis of the irritated vasodilating nerve 

 end-plates and increased vessel-wall permeability, 

 whereby blood-serum oozes into the surrounding tis- 

 sues; it persists through primary antagonistic vaso- 



