A SWEDISH FARMERS LINEAGE 



61 



In the meanwhile, the disease has appeared in the male ancestor's family, 

 but not in the females, and from this fact we can deduct that the male ancestor 

 must have had the propensity and not the female. A sister of the male ancestor 

 must have had the same propensity, because, when a grandchild of hers, married 

 a grandchild of the male ancestor, two of their several children had this serious 



INHERITANCE SCHEME RELATING TO THE FAMILY DISEASE 

 MYOKLONUS EPILEPSY IN BLEKINGE. 



\0 



Hcilc ancester's 

 sister 



Male anccsfgr Female ancester 



®j 



\®_ 



o 



/ 



\0 ^®/ O^ \0 ^®^ O ® O O ^®^ O/ 



u 



m 



^ n-. 



IS rr 



'o ® o ^®' '®i O O ^®' 'O, O O O^ '®j ® o o^ 



^ /^ 



tlarriagc 

 second 



hetweeji Marna<je 



cousins 



b;fivcen 

 cousinb 



R.^laiioiishifj 

 marriage 



\0 ^•/ o ® v®^ /®, o o ®).^ 'o ® ® ^•^ Oy 



Jl 



m 



fiarnaqe^yh^tiueen cousins 



^ ^® ® ® ® ® ® ^®' Oy 'o ® • ®^ 



emigrated to 



yO ®/ 



Australia 



' ^ o, ^ 



^O '®, O O s®_Oj 



Yf 



vzr 



'® P o ^®^ ^®^ ® o o^ ^ 



^O ® O ^®^ ''®^ o ® o^ 



bctu/cen 

 cousins 



Marriage 



fiarrlage 

 cousins 



bctiucert 

 in Australia 



^O ^®y O • ® • ® ® xO^ o 



'• • • • 



'^^ 'o ® ® o\ 



'o o o o' 



\ w 



vm 



L-Kplanailon of symbols ( • ® O J. 



9 denotes n person affected luitk myoklonus epiUpsij (•recessiue homozLjqot). 



® ■ » » healthli but witk propensiUj f-hcierozimot ) 



O . . heallhij person without propcnsiti) (-dominant Iwmozifqot). 



disease. Both these parents must therefore have been heterozygots, and the pro» 

 pensity must have originated from the male ancestor and his sister, through one 

 of their parents, but not from the female ancestor, or her family. 



The first bearer of the propensity for myoklonus epilepsy of which we have 

 any information thus lived in the 17th century. There we lose all trace. It is 

 impossible to determine whether the propensity has originated in Sweden, or 

 was brought here from some other country. 



Professor Unverricht in Dorpat was the first to describe the disease in 

 question. 



He has observed several cases in one and the same household in Esthonia. 

 It is not only possible, but very probable that these families living in Sweden 

 and Esthonia, had the same root many years ago, for diseases of this type go in 



