154 IMMUNE SERA 



these lines and described the formation of a nephro- 

 toxic serum which caused albuminuria and acute 

 degeneration of the kidney without changes in 

 the other organs. Albuminuria appeared gene- 

 rally on the fourth or fifth day, increased rapidly 

 in amount, and was accompanied by the excretion 

 of hyaline and granular casts. Subsequently Pearce 

 and Jackson, 1 after a careful experimental study on 

 the production of cytotoxic sera by the injection of 

 nucleo-proteids, conclude " that the results do not 

 support the theory that specific cytotoxic sera may 

 be developed in this way, but indicate, rather, that 

 such sera have certain mildly toxic properties acting 

 in a general way and affecting especially the principal 

 excretory organ, the kidney." 



1 R. M. Pearce and Holmes Jackson, Journal of Infectious 

 Diseases, Vol. iii, 1906. 



