ANAPHYLAXIS 



171 



weeks or even months. The hypersusceptibility 

 is transmitted from mother to offspring, and may 

 also be passively transferred to other animals by 

 transferring some of the serum of the sensitized 

 animal to normal animals. Animals recovering 

 from the symptoms induced by the second injection 

 are thereafter no longer hypersensitive to the pro- 

 teid employed, but are immune. This immunity 

 is spoken of as " antianaphylaxis." This condi- 

 tion can also be brought about artifically by inject- 

 ing the animals after they have received their 

 sensitizing injection and just before the end of 

 the anaphylactic incubation time, with compara- 

 tively large quantities of the same proteid. Rosenau 

 and Anderson have shown that animals may be 

 sensitized by feeding them with the proteid. 

 Whether this has any practical application to the 

 clinical use of specific immune sera derived from 

 horses in persons habitually eating horse flesh is not 

 known. 



Serum Rashes. Turning our attention for a 

 moment to the serum rashes, we find that in 1874 

 Dallera reported that urticarial eruptions might 

 follow the transfusion of blood. Neudorfer as well 

 as Landois also refer to this complication. In the 

 year 1894 the use of diphtheria antitoxin introduced 

 the widespread practice of injecting human beings 

 with horse serum. In the same year several cases 

 were reported in which these injections were fol- 



