THERAPEUTIC STUDIES ON JONS. 79 



occurs also in the urine. The sulphocyanate of the 

 urine might well, however, be absorbed from the saliva, 

 for, according to GSCHEIDLEN, it disappears entirely from 

 the urine of the dog as soon as the excretory ducts of the 

 salivary glands are turned outward. 



As to where in the body sulphocyanate is formed, is 

 still unsettled; we know something, however, of the 

 manner in which it is produced. S. LANG has shown 

 that all cyanides and nitrils are converted into sulpho- 

 cyanates in the organism. This change probably occurs 

 through a process of association with the neutral sulphur 

 of the proteins, for I succeeded in bringing about such 

 a synthesis years ago in HOFMEISTER'S laboratory with 

 proteins and their derivatives, provided they had not first 

 been robbed of their readily removable sulphur group. 



Recent experiments of BRUYLANTS indicate that a 

 relation exists between the metabolism of the sulpho- 

 cyanates and that of the purin bodies. In an investiga- 

 tion characterized by originality and far-sightedness, and 

 carried on in 1853 in the Wiener Institut fur patho- 

 logische Chemie, KLETZINSKY made valuable contribu- 

 tions to our knowledge of the excretion of sulphocyanate 

 in healthy and diseased su jects, which have in the main 

 been corroborated, most recently by GROBER. The 

 intoxication after large subcutaneous doses of sulpho- 

 cyanate was studied twenty-seven years ago by PASCHKIS 

 on dogs, rabbits, and frogs. Valuable experiments on 

 the effect of sulphocyanate on the metabolism of man 

 and animals have in recent years been made by TREUPEL 

 and EDINGER. MUCK recently discovered sulphocyanate 

 as a separate secretory product in the conjunctival and 

 olfactory secretions. 



