THERAPEUTIC STUDIES ON IONS. 83 



in this field. A steady drop in blood-pressure, amounting 

 from 10 to 25 per cent, of the original value, could be ob 

 served within a few days in all the cases studied. As soon 

 as the drug was stopped the blood-pressure rose again, 

 often to the original height within three to four days. Ac- 

 companying this, there was also a return of some of the 

 previous symptoms. Of interest are two further cases 

 of sclerosis of the larger arteries. One of these was a 

 female patient with sclerosis of the abdominal aorta, which 

 could with its large branches be readily palpated and 

 which gave rise to severe attacks of pain in the abdomen ; 

 the other, a woman with all the signs of an advanced 

 arteriosclerosis, who had suffered for months with pain 

 and weakness in the right arm, which appeared on the 

 slightest exertion or when the arm was allowed to hang 

 by the side for some time. Besides this there existed 

 a so intense and painful sense of cold in the diseased 

 extremity, which corresponded with a very noticeable 

 decrease in the temperature of the skin, that the lower 

 arm and the right hand had always to be wrapped in 

 thick cloths. After a test had been made with sodium 

 bromide and aspirin, and these had proved entirely with- 

 out effect, the pains diminished very markedly after an 

 eight days' use of diuretin. After taking sodium sulpho- 

 cyanate for a number of weeks the sensation of cold 

 gradually disappeared, the hand no longer needed to 

 be wrapped in cloths, and the weakness in the ex- 

 tremity disappeared sufficiently so that the patient, who 

 had .been under observation for eight months, was able 

 to do light work about the house. The blood-pressure 

 fell during this time from 210 to 160 mm. of mercury. 

 The patient with arteriosclerotic pains in the splanchnic 



