THERAPEUTIC STUDIES ON /OAtt, 87 



cases that an existing chronic albuminuria does not 

 contraindicate the use of the drug. 



My last observations are taken from a group of patients 

 with syphilitic headaches two men and two women. 

 In the men there was a history of syphilitic infection ; in 

 the women abortions and still- births had occurred. One 

 man and one woman had a year previously suffered from 

 the same symptoms, which had promptly disappeared 

 after the use of iodides, and only after these. The head- 

 aches were in all cases very severe, and in three of them 

 typically nocturnal in character, particularly during the 

 weeks when this symptom first developed. Sensitiveness 

 of the skull upon percussion also existed. 



The syphilitic character of the pains was therefore 

 definitely established in these cases, so far as this is 

 clinically possible. This diagnosis was further strength- 

 ened by the uselessness clinically of physical healing 

 methods and antineuralgic remedies. 



The effect of the sulphocyanate in these cases was so 

 prompt and so clearly beneficent, even in the first few 

 days after administration, that its medicinal properties 

 cannot be doubted.* The effect upon the patients 

 proved in all cases to be a lasting one. The two patients 

 who had for similar symptoms previously undergone a 

 treatment with iodides agreed that the feeling of relief 

 had this time come much more promptly. In one of 

 the patients, who could tolerate drugs only badly and 

 who had a year previously suffered from severe iodism, 



* I do not, of course, on the basis of these few observations on a 

 special form of late syphilis, want to look upon the question of the 

 specific effects of a sulphocyanate therapy in syphilis as settled. 



