88 PHYSICAL CHEMISTRY IN MEDICINE. 



the sulphocyanate was administered in two small enemas 

 daily. 



This constitutes a summary of my experiences thus 

 far. They were obtained for purposes of general 

 orientation on patients of whom each group presented a 

 great, almost monotonous similarity in symptoms. When 

 the careful choice of cases is taken into consideration, 

 it can scarcely seem strange that the effect of the drug 

 should have been so uniform. In passing it must have 

 been apparent what small doses of sodium sulphocyanate 

 proved remedially effective. The explanation of this 

 fact lies in part in the low molecular weight of the sub- 

 stance, for i.o gram sodium sulphocyanate is equal to 

 2.15 grams sodium bromide or 2.82 grams sodium 

 iodide. 



But a close relationship between these substances 

 shows itself not only in the harmony of their advantages, 

 but also in the harmony of their disadvantages. There 

 exists a sulphocyanate acne and a sulphocyanate rhinitis. 

 The latter is the commoner. Twice a mere sugges- 

 tion of it occurred, in one of these cases only once toward 

 evening. In two other cases copious secretion from 

 the nose and eyes set in, which disappeared, however, 

 within two to three days after the administration of 

 sulphocyanate was stopped. In only one patient with a 

 sensitive skin, which had some months previously been 

 the seat of a bromide exanthem, a sulphocyanate acne 

 appeared, consisting of small nodules, most numerous 

 in the face and sparingly distributed over the trunk and 

 extremities, which did not, however, give any further 

 trouble. It disappeared a few days after the medication 

 was stopped. Gastric disturbances never appeared,, even 



