2i8 FEVER AND 



If, on the other hand, the changes have proceeded to 

 a degree sufficient to prevent the capillary circulation 

 over a considerable portion of the body or through- 

 out the greater part of one or more organs, the 

 integrity of which is necessary to life, recovery is no 

 longer possible, and death must result. 



The actual changes which take place in the vessels 

 and tissues will be understood if the reader will 

 attentively examine the drawings in Plate XXVIII, 

 which well illustrate the striking alterations which 

 occur in the bioplasm or germinal or living matter of 

 the tissues and vessels in fever. Figs. 114 and 115 

 represent respectively the bioplasm of connective 

 tissue in health, and in fever. The amount in the 

 diseased connective tissue is many times greater than 

 in the healthy specimen. The masses of bioplasm of 

 the capillary represented in Fig. 116, are more than 

 three times as large as they would be in a state of 

 health, and the same remark applies to the little 

 artery represented in Fig. 117. In both these figures 

 the bioplasm is already beginning to divide and sub- 

 divide, and had life been prolonged for a few days, 

 numerous separate particles, like pus-corpuscles, would 

 have resulted. In very bad cases of fever which are 

 fatal, similar changes may be demonstrated in the 

 textures in all parts of the body ; and in every case 

 of local inflammation precisely corresponding pheno- 

 mena are found at the seat of pathological change. 



The rise in temperature, be it restricted to a part 



