METABOLISM, NUTRITION, AND DIET 



show that the anterior and posterior lobes are not concerned with identical 

 functions. Attempts to arrive at the knowledge of the proper physiology 

 of the organ have been made primarily along three experimental lines; i, 

 Removal of the gland in whole or in part; 2, Transplantation; 3, The feed- 

 ing or the injection of extracts. 



FIG. 319. Enlarged view of the square marked on Fig. 318. (Gushing and Goetsch.) 



b. Functional Disturbances After Complete Removal of the Pituitary. 

 Removal of the gland is followed by death of the operated animals, in old 

 dogs in from three to five days, but puppies survive ten to thirty days 

 (Gushing). The acute symptoms are: insensitiveness, slow pulse and 

 respiration, fall in body temperature, apathy, coma, and death. 



If a small part of the gland is left so that only a condition of hypopitui- 

 tarism is induced then the symptoms are more pronounced and chronic. 



