THE PITUITARY BODY 



497 



These are summarized by Gushing: " Widespread adiposity, nutritional 

 changes in the skin and its appendages, disturbance of carbohydrate 

 metabolism, of body temperature, of growth and of renal secretion. 

 Sexual inactivity or actual atrophy of the reproductive glands was 

 observed; and, indeed, modification of most of the other ductless glands 

 proved to be histologically demonstrable." In puppies there was per- 

 sistent "sexual infantilism," " skeletal undergrowth" and "psychic dis- 

 orders." These experimental results throw light on a great mass of 

 clinical evidence which Gushing has gathered and interpreted. 



FIG. 320. High magnification of the square marked on Fig. 319. C, Colloidol ves- 

 icles apparently discharging from C into the tissue spaces of the pars nervosa. H, Hyaline 

 bodies. (Gushing and Goetsch). 



c. Action of Pituitary Grafts, Extracts, Etc. Transplantation of the pitui- 

 tary into the cerebral cortex prolonged the life of Cushing's animals. The 

 gland gave histological evidence of viability for a month. Grafts have not, 

 however, been umformally and permanently beneficial, and do not produce 

 evidences of hyperpituitarism. 



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