20 Professor Halford. 



affected by it. As .many as five or seven of these 

 large nucleated cells were seen at one time in the 

 field of the microscope. The granular nucleus was 

 very distinct, and appeared to be adherent to the 

 inner side of the delicate, though distinct, cell-wall. 

 Although these nucleated cells were numerous, we 

 were unable to detect the circular patches (maculae) 

 depicted by Professor Halford, and which he states 

 were coloured by carmine. 



" Whatever be the result of further investigation, 

 there could be no doubt of the appearances here 

 described, for they were peculiarly obvious. The 

 absence of any such appearance in this dog's blood 

 was equally certain." 



COMMENTS. 



It is a pity that Dr. Fayrer and Dr. Macnamara did 

 not more carefully examine the remarkable appearances 

 they describe, and that they did not take the diameters 

 of the "large cells." I made them on the average 

 -^ inch. Dr. Martin, who has lately made independent 

 measurements, comes to the same conclusion. No one 

 who has ever seen these cells could doubt their identity 

 with those I described. No one, as I stated in 1873, 

 can expect to find them in blood drawn soon after death ; 

 they are a post-mortem fact, increasing in size and 

 apparently in numbers, whilst the red corpuscles are 

 spherical, not bi-concave, and have shed their haemo- 

 globin, which may frequently be seen in the form of 

 crystals in the field. 



