48 Professor Halford. 



Result. In twenty minutes he became quite insen- 

 sible, the limbs were flaccid, and the pupils widely 

 dilated. Respiration slow and deep. Circulation most 

 feeble. Thinking he might die, I injected m. xxv of 

 liquor ammonias into a vein. 



. Result. Almost immediately the heart's action was 

 quicker and more forcible. The limbs and tail became 

 extended. The pupils contracted, and reflex acts 

 followed touching the eyelids. Respiration soon be- 

 came re-established, and the dog completely recovered. 



Thinking it better to introduce the chloral more 

 gradually, I proceeded as follows : 



EXPERIMENT. 



One drachm was dissolved in one ounce of warm 

 distilled water, and injected into the peritoneal cavity 

 of another dog. 



Result In three minutes he lay down, and in six 

 minutes was quite insensible, so that I amputated 

 both hind limbs, before he woke up, which he soon did 

 completely. 



I repeated this last experiment, and was struck by 

 the .fact that this dog also became affected in three 

 minutes, and insensible in six minutes. 



This gave me some idea of the time required for the 

 solution to be absorbed through the peritoneal mem- 

 brane, and to produce its narcotic effect on the brain. 



EXPERIMENT. 



Six other dogs were similarly treated, and each lay 

 down in three minutes, and became insensible in six. 



