THE REGULATION OF GASTRIC SECRETION. 180 



siEWicz, 1 who in 1875 followed the principle adopted byTniRY 

 for the intestine, and attempted the isolation of a part of 

 the stomach into a closed pouch which opened externally. 

 His dog lived, however, only three days. HEIDENHAIN 2 soon 

 after repeated the operation and succeeded in keeping his 

 animal alive. Pure gastric juice can be obtained from a 

 dog operated upon in this way. It is only necessary to 

 introduce food into the large stomach, when a flow of per- 

 fectly pure gastric juice will take place from the isolated 

 cul-de-sac. 



The operation of HEIDENHAIN possesses the important 

 defect of interfering with the nerve-supply of the stomach. 

 To overcome this objection PAWLOW and ORIGIN 3 have 

 devised an operative procedure which will be described 

 in some detail, as its use has done much to give us a clearer 

 insight into the physiology of the stomach. An incision is 

 made into the stomach, which begins in the fundus a little 

 below the pylorus and runs longitudinally toward the car- 

 dia. This incision divides both anterior and posterior 

 walls (AB, Fig. 20, I). The triangular flap thus formed 

 is made into a cylinder, the orifice of which is sewed into 

 the abdominal wall, while its base is still connected with 

 the main cavity of the stomach. The cavity of the stomach 

 and that of the pouch do not, however, communicate with 

 each other, but are separated by a septum of mucous mem- 

 brane, as indicated in Fig. 20, II. The opening in the main 

 stomach cavity is closed by a line of sutures. 



In order to obtain gastric juice from the miniature stomach 

 (S, Fig. 20, II) a small India rubber or glass tube, freely 

 perforated at its lower end, is introduced through the opening 

 in the abdominal wall (A A) into the pouch. The tube remains 



1 KLEMENSIEWICZ : Sitzungsberichte d. Wiener Akad., 1875, Bd. 

 LXXI. 



2 HEIDENHAIN: Pfliiger's Archiv, 1878, XVIII, p. 169. 



8 PAWLOW and CHIGIN: PAWLOW'S Work of the Digestive Glands. 

 Translated by THOMPSON, London, 1902, p. 11. 



